jjhunter: Drawing of human JJ in ink tinted with blue watercolor; woman wearing glasses with arched eyebrows (JJ inked)
jjhunter ([personal profile] jjhunter) wrote in [personal profile] xiphias 2016-02-19 07:31 pm (UTC)

I wonder how long it will take them to incorporate that WHEN you eat also matters — there's a circadian rhythm to glucose tolerance, so the same exact meal eaten by the same person will result in different levels of blood sugar, insulin release, and insulin sensitivity depending on whether that meal was eaten during the person's biological morning vs evening. (This is part of why night shift work is a major risk factor for diabetes and weight gain - meal timing is out of alignment with when your innards expect you will be eating vs sleeping, and the general state of circadian misalignment reduces the amplitude of your metabolic rhythms to boot.)

Or another way to put it: how your body will break down and store vs make immediate use of those fats, proteins, sugars, & nutrients will vary by biological time of day even after accounting for physical activity level and all the other usual confounders. So if you're trying to 'watch' how what you eat will impact your weight, when you eat is like a slight multiplier or divider for every meal depending on the timing, with measurable impact over weeks. (Biological morning -> more immediate burning, less storing vs. eating later in one's biological day.)

/yearns for fitbit equivalent for circadian rhythms - some easy way to measure when it is in one's biological time without having to repeatedly sample salivary or plasma melatonin levels or internal temperature. Most people's biological time stays at a consistent phase within an hour or two relative to local clock time if they aren't jetlagged or on night shift, but that can still mean 9am for one person can be biologically like being a time zone away in one direction (~10am), and for another is like being two (or even three) time zones away in the other direction (~7am or ~6am).


Jakubowicz, Daniela, Maayan Barnea, Julio Wainstein, and Oren Froy. "High caloric intake at breakfast vs. dinner differentially influences weight loss of overweight and obese women." Obesity 21, no. 12 (2013): 2504-2512.

Morris, Christopher J., Jessica N. Yang, Joanna I. Garcia, Samantha Myers, Isadora Bozzi, Wei Wang, Orfeu M. Buxton, Steven A. Shea, and Frank AJL Scheer. "Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans." Proceedings of the National Academy of Sciences 112, no. 17 (2015): E2225-E2234.

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